Figure 2 lists various vaginal dosage forms and the classes of excipients used in them. A therapeutic pessary is a medical device similar to the outer ring of a diaphragm. There are a variety of vaginal pessaries, but the two different types of pessary that we most commonly use are ring and shelf pessaries. How to use rectal suppositories properly wash your hands thoroughly with soap and water. If the suppository is soft, hold it under cool water or place it in a refrigerator for a few minutes to harden it before removing the wrapper. You can use a vaginal pessary if you would prefer to. Remove plastic cover from the suppository before use. Comparative bioavailability of orally and vaginally. This can be partly attributable to the immiscibility of some of the. Heres how they work, how they help, and how you should care. Webmd explains what they treat and how to use them.
The name of your medicine is utrogestan vaginal 200mg capsules called utrogestan vaginal in this lea. Compendium of pharmaceutical excipients for vaginal formulations. Pessary is an interchangeable term, referring specifically to a vaginal suppository. In modern days most of the remedial medicines are prepared for rectal delivery to gain therapeutic blood concentration of the. Methods of preparation university of north carolina at. Formulation and evaluation of vaginal suppositories. Suppositories and pessaries free download as powerpoint presentation. After insertion they melt or soften at body temperature, whereas vaginal suppositories sometimes called as pessaries. A suppositories is a drug delivery system that is inserted into the rectum rectal suppository, vagina vaginal suppository or urethra urethral suppository. Pdf in the last decade, interest in developing a combination of two or more drugs in a single dosage form has increased in the pharmaceutical. Jan 06, 2015 rectal suppositories for adults weigh 2 gm and are torpedo shape. Elixir are clear, sweetened, aromatic hydro alcoholic liquids intended for oral use. Care of your vaginal pessary patient information partnering with consumers standard 2 consumers andor carers provided feedback on this patient information.
Vaginal formulations are not only available in modern allopathic systems of medicine but also in traditional systems of medicine. Pdf metronidazole bioadhesive vaginal suppositories. Designing and developing suppository formulations for antihiv. Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. Digoxin capsulesfor atrial fibrillation in children zslti s i e li mit solutions, suspensions, emulsions, mixtures. The tested suppository showed enhancement of drug absorption from tested suppository and the one way anova analysis for auc0. As nouns the difference between suppository and pessary is that suppository is a medicine in the form of a small plug that is inserted into a bodily cavity, especially the rectum, vagina or urethra, where it melts at body temperature while pessary. The glycerol suppository mass contains 70% glycerol, 1420% gelatin, and 1016% water. Suppositories are soliddosageformsintended for insertionintobodyorificeswheretheymelt,soften,or.
Department of urogynaecology vaginal pessary for prolapse. Molding is the most frequently used method for both small and commercial scale preparation of suppositories the following are the steps to prepare suppositories by molding. Preparation and evaluation of novel vaginal pessaries. High concentration of gelatin is used for hot climates or to counteract the effect of the liquid ingredient. The shapes of suppositories, pessaries, and bougies conform more or less to that of a riflebullet. Rectal suppositories intended for localized action are. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach.
Jun 24, 2016 37 suppositories and pessaries arthur j. The uniformity of texture can be assessed by sectioning a suppository longitudinally and. Suppositories and pessaries thedisintegration testdetermineswhether thesuppositories or pessaries soften or disintegrate within the prescribed time when placed in a liquid medium in the experimental conditions described below. Suppositories and pessaries is the property of its rightful owner. They support the vaginal wall and help correct the position of displaced pelvic organs. Winfield study points ideal suppository bases types of base suppository moulds and mould calibration displacement values methods of preparation of suppositories and pessaries containers, labelling and patient advice for suppositories and pessaries introduction drug administration by the rectum can be used for local or systemic action. Dulcolax prescribing information page 7 of 12 for diagnostic procedures or preoperatively to achieve complete evacuation of the intestine. Paracetamol release from palm oil suppositories is rapid and. Rectal suppositories for adults weigh 2 gm and are torpedo shape. Dec 26, 2016 advantages and disadvantages of suppositoriespessaries or rectalvaginal route of drug administration bliss gvs pharma limited uncategorized advantages and disadvantages of suppositoriespessaries or rectalvaginal route of drug administration. The rate and extent of rectal drug absorption are often lower than with oral absorption possibly an. Manufacturers typically recommend storage of xray film at a maximum of 21c. Aromatic suppositories and pessaries can bring local and systemic relief for a variety of wellness goals. To pass the test all the samples must have disintegrated.
Goals for comppgounding zby the end of this course pharmacy 101 you will have the basic knowledge and skills to commence compounding zby the end of the pharmacy 201 course you will. Suppositories and inserts at massachuetts college of pharmacy. With dual training in both clinical aromatherapy and aromatic medicine i bring a unique skill set to the blending bench when i am formulating suppositories. The larger size moulds are usually used in the preparation of pessaries such as 4 g and 8 g moulds. Pdf drug administration via mucosal membranes, including the vaginal, has the advantage of. Suppositories and pessaries as drug delivery vehicles are not new dosage forms. Feb 06, 2020 unlike for tablets and capsule dosage forms, there are not enough dissolution testing methods or validations for suppositories. The word suppository is derived from the latin suppositorum, which means, something placed beneath. After insertion they melt or soften at body temperature, whereas vaginal suppositories sometimes called as pessaries, are also made as. Suppositories pessaries are a type of suppository intended for vaginal use. Aromatic suppositories, pessaries the barefoot dragonfly. The device fits into your vagina and provides support to vaginal tissues displaced by pelvic organ prolapse.
Suppositories and pessaries unither pharmaceuticals cphi. A diagnostic aid in case of a doubtful atrophic cervical smear 1 pessary on alternate days in the week before taking the next smear. If they do melt, they should not be used because the active ingredient in the formula may become unevenly distributed. Place each oneonthelowerdiscofadevice,placethelatterinthesleeve and secure. As nouns the difference between suppository and pessary is that suppository is a medicine in the form of a small plug that is inserted into a bodily cavity, especially the rectum, vagina or urethra, where it melts at body temperature while pessary is a medical device similar to the outer ring of a contraceptive diaphragm, most commonly used to support a. The united states pharmacopoeia basis is cocoabutter. Vaginal suppositories, also called pessaries, are usually. Rectal drug delivery is one of the worlds oldest strategies for. At the time of the single dose, each subject was at day 4 to 6 of the menstrual cycle to ensure low endogenous p. Suppositories can be extemporaneously prepared by one of three methods. European commission directorategeneral iii industry industrial affairs iii.
The suppository base was prepared by mixing hydrogenated palm oil. Advantages and disadvantages of suppositoriespessaries or. They are commonly used for vaginal and rectal complaints. Study 39 suppositories and inserts flashcards from adam d. Vaginal suppositories or pessaries weigh about 35gm and are molded in globular or oviform shape or compressed on a tablet press into conical shapes. Suppositories, pessaries, enemas suppositories, pessaries, enemas suppository, suppositories, pessary, pessaries, enema. Chapter1 introduction in ancient era, drugs inducing unconsciousness, haemorrhoedal, vermicidel and purgative actions was inserted though rectal route in the form of suppository. The trial, according to a open, noncontrolled design, was performed on 150 postmenopausal women, 1 vaginal suppository per day, for the first 14 days and then a vaginal suppository. These are classed as remedies used externally because they are not taken orally but in a sense they are taken internally in as much as they are inserted into the body.
Suppositories and pessaries chemistry nature scribd. As nouns the difference between suppository and pessaries is that suppository is a medicine in the form of a small plug that is inserted into a bodily cavity, especially the rectum, vagina or urethra, where it melts at body temperature while pessaries is. These tasks are referred to as level 4 and will be the responsibility of the community. As nouns the difference between suppository and pessaries is that suppository is a medicine in the form of a small plug that is inserted into a bodily cavity, especially the rectum, vagina or urethra, where it melts at body temperature while pessaries. Urethral suppositories called bougies are pencil shape.
Healthlink bc, your provincial health line, is as close as your phone or the web any time of the day or night, every day of the year. Suppository quality control includes physical and chemical aspects of the product box 9. What is the difference between pessaries and suppositories. The base is melted and precautions are taken not to overheat it. Suppositories used for systemic and local action pessaries are used only for local action. A suppository is a solid dosage form that is inserted into the rectum rectal suppository, vagina. Chapter 9 quality control of suppositories 141 box 9. Compounded suppositories can be checked for calculations of theoretical and actual weight and weight variation,color,hardness, surface texture, and overall appearance. Traditional metal moulds are in two halves which are clamped together with a screw. Preparations for oral use zcld p g lcapsules, powders, granules solid dosage forms for oral use e. Examine the samples after the period prescribed in the monograph. Suppositories should melt at just below body temperature 37 c, which allows for erosion of the dosage form and release of the api. Vaginal pessaries are soft, removable devices that help relieve the pressure and discomfort caused by pelvic organ prolapse pop.
Your doctor can fit you for a pessary and help you decide which type would best suit your needs. Presentations ppt, key, pdf logging in or signing up. These products may melt at temperatures greater than 30c. Clotrimazole belongs to a group of medicines called azoles and is an antifungal agent which fights the cause of infections such as vaginal thrush. Suppositories allow for the insertion of herbal preparations into a body orifice. High concentration of gelatin is used for hot climates or to counteract the effect of. Suppositories are solid medicated preparations designed for. Chemical testing includes analysis of the activity and dissolution testing. If so, share your ppt presentation slides online with. Comprises of mixture of glycerol and water gelled, by gelatin. Effectiveness and safety of vaginal suppositories for the. Suppository base excipients are used in the manufacture of suppositories for rectal administration and pessaries for vaginal administration. We performed a retrospective cohort study of women who underwent a pessary fitting from 1 january 2007 through 1 september 20 at one institution.
Quality control of suppositories pharmaceutical press. Four kinds of vaginal suppositories containing lactobacillus paracasei hl32 were formulated. Pessaries are used almost exclusively for local medication, the exception being prostaglandin pessaries. Therapeutic pessaries are used to support the uterus, vagina, bladder, or rectum. Two to four coated tablets 10 20 mg, orally the night before the procedure, followed by one suppository. Metronidazole suppositories were prepared using different suppository bases viz. One package of japanese pessaries 1936in the 1936 case united states v. Evaluation of palm oilbased paracetamol suppositories by. Ppt suppositories and pessaries powerpoint presentation. Medication management support aberdeen city health and social. Similarly, any added medicinal agent alters the density of the base, and the weight of the resulting suppository. Bilayered suppository is a novel pharmaceutical technology for the. Winfield study points ideal suppository bases types of base suppository moulds and mould calibration displacement values methods of preparation of suppositories and pessaries containers, labelling and patient advice for suppositories and pessaries. Fattype suppository bases can be produced from a variety of vegetable oils, such as coconut or palm kernel, which are modi.
Scribd is the worlds largest social reading and publishing site. The active substance in canesten 500mg pessary is clotrimazole. Some suppositories, pessaries, creams, and ointments. Utrogestan vaginal contains a hormone called progesterone. Classification of suppositories rectal suppositories vaginal suppositories pessaries urethral suppositories bougies nasal suppositories ear suppositories. Consumer goods industries pharmaceuticals and cosmetics.
Melt the baseadd the drug to the basepour the melts into moldsallow the melt to cool and congeal into suppositories remove the hardened suppositories from the mold. Definition a suppository is a medicated solid dosage form generally intended for use in the rectum, vagina and to a lesser extent, the urethra. Hand rolling is the oldest and simplest method of suppository preparation and may be used when only a few suppositories. Dr sabine kopp, medicines quality assurance programme, quality assurance. Suppositories and pessaries are an ideal mode of administration of a drug when the oral route is not possible due to nausea or vomiting.
1375 165 1454 265 1335 635 463 1177 1067 893 901 154 619 1167 59 1006 448 756 1559 1470 168 555 1174 1282 1350 100 526 127 1111 457 1407 500 404 1209 959 1434 519 956 1198 1492 453 62 288